Best .22-250 Remington Ammo

The .22-250 Remington is one of the fastest commercially available rifle cartridges, delivering blistering velocities that have made it a legendary choice for varmint hunters since its standardization in 1965. Originally developed as a wildcat cartridge in the 1930s by necking down the .250 Savage case to accept .224 caliber bullets, the .22-250 quickly earned a reputation for exceptional accuracy and flat trajectory that few cartridges can match.

With muzzle velocities ranging from 3,500 fps with heavier 64-grain bullets to an astounding 4,450 fps with lightweight 35-grain projectiles, the .22-250 Remington excels at reaching out across open terrain where prairie dogs, ground squirrels, and other varmints present challenging targets. The cartridge's high velocity translates to remarkably flat trajectories, minimal wind drift at moderate ranges, and explosive terminal performance on thin-skinned game. These characteristics have made it the go-to choice for serious varmint hunters across the American West.

Beyond varmint hunting, the .22-250 has proven itself as an effective predator cartridge for coyotes and foxes, particularly when loaded with heavier bullets in the 55-64 grain range. The combination of accuracy, velocity, and manageable recoil makes it an excellent choice for hunters who need to make precise shots at varying distances. Whether you're protecting livestock from predators or spending a day at a prairie dog town, the .22-250 Remington delivers the performance that has kept it popular for over half a century.